CMF: Coupled Mutation Finder



CMF is a new entropy-based method to quantify phylogenetic noise for the detection of significant compensatory mutations. It is developed to predict  structurally or functionally important residue sites in  protein sequences, which are likely to affect protein stability or functionality. These important sites can be further used to detect disease associated amino acid mutations (non-synonymous single nucleotide polymorphisms (nsSNPs)), responsible sites for the maintenance of internal protein volume, possibly  key sites for the interaction within or between proteins, and the sites in protein sequences.

Theoretical Computer Science and Algorithmic Methods Department of Bioinformatics
University of Göttingen